No. 11 Midwestern State raced out to an early and cruised to an 86-69 win over Southern Indiana in the finale of the Bill Joergens Memorial Classic at the USI Physical Activities Center.
Southern Indiana had won 51 consecutive non-conference games at home before suffering its first setback since falling to Northwest Missouri in 2007-08.
The Mustangs (5-1) raced out to an 11-2 lead ignited by a 3-pointer by senior guard Bretson McNeal, who also hit a jumper during an 11-0 run after Southern Indiana scored the first bucket off the game on a Bobo Drummond jumper.
MSU led by as many as 16 points in the first half as the Mustangs shot 56.3 percent from the field while getting out on the break for 10 points in transition.
Southern Indiana opened the second half on a 10-0 run to pull within 45-40 when Jeril Taylor canned a 3-pointer with 16:08 to play, but the Screaming Eagles would get no closer.
The Mustangs used an 11-1 run spurred by a pair of 3s by Brandon Golden and another triple by Jordan Stevens as MSU pushed the lead back out to 15 at 73-58 with 3:56 to play.
The lead would balloon to 20 when Stevens drove the paint for a layup with 14 seconds remaining.
McNeal paced Midwestern with 17 points and six rebounds hitting three 3-pointers, while senior forward Khapri Alston notched his third double-double of the season with 16 points and 10 rebounds.
Stevens chipped in 16 points of his own to go along with five assists, while Golden scored in double figures off the bench for the second straight night finishing with 11 points with a pair of 3s.
Taylor had 15 points and 10 rebounds to pace Southern Indiana, who fell to 4-2 on the season.
Midwestern State plays host to St. Mary's (Texas) Tuesday night at D.L. Ligon Coliseum. Tipoff is set for 7:30 p.m.