(RNN) - Charlie Murphy, 57, the comedian and performer, has died, his publicist said Wednesday.
He died at a New York City hospital Wednesday morning, the New York Daily News reported. Murphy's manager told Daily Beast that the actor had leukemia and had been undergoing treatment.
Charlie Murphy is best known for his appearances on Chappelle's Show.
He recently had been on the Comedy Get Down tour with fellow standups George Lopez, D.L. Hughley, Cedric the Entertainer and Eddie Griffin.
His last tweet contained mindfulness advice: "One to Sleep On: Release the past to rest as deeply as possible."
The segment "Charlie Murphy's True Hollywood Stories" appeared in season 2 of Dave Chapelle's Comedy Central show. Murphy, a cast member of Chapelle's show, described encounters with singer Rick James at parties, as Chapelle played the funk musician on screen.
The episode became one of the show's most well-known bits. A second one, describing an encounter with Prince, also was made in season 2.
He also has performed standup comedy tours for several years, according to his website.
Charlie Murphy has appeared in several feature films, including The Guys Who Move Furniture, Lottery Ticket, Our Family Wedding, A Perfect Holiday, Kings Ransom, Roll Bounce, Chris Rock's classic hip-hop parody CB4, Spike Lee's Jungle Fever and Mo' Betta Blues, Unearthed, Night At The Museum and Harlem Nights.
He voiced Ed Wuncler III on Adult Swim's Boondocks, and had several screenwriting credits, including Norbit, which starred his brother Eddie Murphy.
Rock expressed his grief on Twitter Wednesday, saying, "We just lost one of the funniest most real brothers of all time."
Charlie Murphy's wife, Tisha Taylor Murphy, died of cancer in 2009. He has three children, including two with his wife and one from a previous relationship, the Daily News said.
Charlie Murphy is Eddie Murphy's only brother.